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the target has been reached Unlike familial and parkinsonian tremors, the oscillations occur in more than one plane The tremor and ataxia may seriously interfere with the patient s performance of skilled acts In some patients there is a rhythmic oscillation of the head on the trunk (titubation) or of the trunk itself at approximately the same rate As already indicated, this type of tremor points to disease of the cerebellum or its connections, particularly via the superior cerebellar peduncle, but certain peripheral nerve diseases may occasionally simulate it As remarked on page 76, there is another, more violent type of tremor associated with cerebellar ataxia, in which every movement, even lifting the arm slightly or maintaining a static posture with the arms held out to the side, results in a wide-ranging, rhythmic 2- to 5-Hz wing beating movement, sometimes of suf cient force to throw the patient off balance In such cases, the lesion is usually in the midbrain, involving the upward projections of the dentatorubrothalamic bers and the medial part of the ventral tegmental reticular nucleus Because of the location of the lesion in the region of the red nucleus, Holmes originally called this a rubral tremor However, experimental evidence in monkeys indicates that the tremor is produced not by a lesion of the red nucleus per se but by interruption of dentatothalamic bers that traverse this nucleus ie, the cerebellar efferent bers that form the superior cerebellar peduncle and brachium conjunctivum (Carpenter) This type of tremor is seen most often in patients with multiple sclerosis and Wilson disease, occasionally with vascular and other lesions of the tegmentum of the midbrain and subthalamus, and rarely as an effect of antipsychotic medications It is abolished by a lesion in the opposite ventrolateral nucleus of the thalamus Betaadrenergic blocking agents, anticholinergic drugs, and L-dopa have little therapeutic effect Thalamic stimulation may be helpful in severe cases that are the result of multiple sclerosis lesions in the cerebellar peduncles The mechanisms involved in the production of intention or ataxic tremor have been discussed in Chap 5 Geniospasm This is a strongly familial episodic tremor disorder of the chin and lower lip that begins in childhood and may worsen with age Psychic stress and concentration are known to precipitate the movements, which are described by Danek as trembling Rare instances involve other facial muscles The disorder must be distinguished from essential tremor, facial myokymia, and palatal tremor The trait is inherited in an autosomal dominant fashion from a locus on chromosome 9 Primary Orthostatic Tremor This is a rare tremor isolated to the legs that is remarkable by its occurrence only during quiet standing and its cessation almost immediately on walking It is dif cult to classify and more relevant to disorders of gait than it is to tremors of other types The frequency of this tremor has been recorded as approximately 14 to 16 Hz, making it dif cult to observe and more easily palpable Nonetheless, it may produce considerable disability as the patient attempts to stabilize himself in response to the tremulousness An important accompanying feature is the sensation of severe imbalance, which causes the patient to assume a widened stance while standing; these patients are unable to walk a straight line (tandem gait) We have observed prominent tonic contraction of the legs during standing, seemingly in an attempt to overcome imbalance (see Heilman, Thompson et al) Falls are surprisingly infrequent; therefore the condition is often attributed to hysteria The arms are affected little or not at all Often the.

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rst step or two when the patient begins to walk are halting, but thereafter, the gait is entirely normal Tremulousness is not present when the patient is seated or reclining, but in the latter positions it can be evoked by strong contraction of the leg muscles against resistance Although some authors such as Wee and colleagues have classi ed the disorder as a type of essential tremor, most of its characteristics suggest otherwise The suggestion has been made by Sharott and colleagues that it represents an exaggerated physiologic tremor in response to imbalance; others have found an intrinsic rhythm at approximately 16 Hz generated by the damaged spinal cord in patients with myelopathy, suggesting a spinal origin for the tremor Many of these cases have responded to the administration of clonazepam, gabapentin, mysoline, or sodium valproate Dystonic Tremor Also dif cult to classify but not to be overlooked are tremors that are intermixed with dystonia They tend to be focal in the neck, which is typically rotated slightly to one side, or they may be evident in one dystonic hand The tremor is not entirely rhythmic, sometimes jerky, and often intermittent When the underlying dystonic posturing is not overt, the tremor may be ascribed to an obscure origin These cases are discussed further on, in the section on focal dystonia In addition, a fair number of patients with dystonia have an essential tremor

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single join back to the fact table to speed performance In Oracle8, the optimizer added more advanced techniques to be used where the number of dimensions was quite large or data within such tables was found to be sparse Star query optimization typically occurs today on such schemas where a bitmap index is created on the foreign key column in the fact table and the Oracle database initialization parameter STAR_TRANSFORMATION_ ENABLED is set to TRUE Of course, many queries are submitted by business analysts that return answer sets containing subtotals or summaries of detailed data For example, a query might be issued to return results of shipments by region over the past six months against the schema illustrated earlier in Figure 7-2 For those sorts of queries that can rely on summary data (such as regions in our example schema), Oracle introduced materialized views in Oracle8i Essentially, materialized views are physical tables in the Oracle database containing the aggregated or summary-level data, so regions might be deployed in materialized views A faster answer to the query occurs because the query is transparently redirected to the aggregated data table and detailed data does not need to be scanned to provide the answer Over subsequent releases of the Oracle database, the optimizer made better use of materialized views so that today, they can be joined even where they don t align at exactly the same levels of detail The creation of materialized views also became much more automated since Oracle s Automatic Database Diagnostics Monitor can make recommendations as to where materialized views are useful, the materialized views advisor in Oracle Enterprise Manager can recommend their creation, and DBAs can simply respond positively to the recommendation to create them An additional database feature, the Oracle database Partitioning Option, is more often associated with effective Oracle data warehouse management We will describe its importance in enabling an effective loading and backup strategy in a few sections But the Oracle Partitioning Option also has important implications for query optimization The Oracle Partitioning Option is used simply to separate the database into smaller sets of data, using ranges, hashes, or other means of distributing the data The most popular strategies for using the Partitioning Option are to manage the database based on a range of dates, or a range of values, or a composite mix of the two However, since many queries also often map to specific date ranges or values when determining results, the Oracle optimizer is smart enough to direct queries to only the partitions that.

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public FileStreamResult Print (int id) { var model = _CustomRepository.Get(id); this.ConvertToPDF = true; return View ( "HtmlView" ); } public ...

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return new FileStreamResult(pdfStream, "application/pdf") ... The above is an aspx client page, but the concept for MVC is the same....get the ...

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